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RG7388
Item number: Cay21532-1
RG7388 is a non-imidazoline, selective MDM2 inhibitor that blocks the binding of MDM2 to p53 (IC50 = 30 nM). By inhibiting MDM2, RG7388 activates the p53 pathway in SJSA1 osteosarcoma cells and inhibits the growth of xenografts in nude mice. RG7388 is orally available and prolonged daily administration results in...
| Keywords: | Idasanutlin, Ro 5503781,... |
| Application: | MDM2 inhibitor |
| CAS | 1229705-06-9 |
| MW: | 616.5 D |
From 71.00€
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Idasanutlin
Item number: TGM-T6254-100mg
Description: Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM). Target: E1/E2/E3 Enzyme, Mdm2. Smiles: COc1cc(ccc1NC(=O)C1NC(CC(C)(C)C)C(C#N)(C1c1cccc(Cl)c1F)c1ccc(Cl)cc1F)C(O)=O. References: Ding Q, et al. J Med Chem. 2013, 56(14), 5979-5983.
| Keywords: | Ro 5503781, RG7388 |
| Application: | Targets E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27] (MDM2) |
| CAS | 1229705-06-9 |
| MW: | 616.48 D |
From 33.00€
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Idasanutlin
Item number: BPS-82074
Potent MDM2 inhibitor with an IC50 = 6 nM in binding assay and 30 nM in cancer cell proliferation assay. Induces p53 stabilisation, cell cycle arrest and apoptosis in cancer cells expression wildtype p53. Displays inhibition of tumor growth in the SJSA1 tumor xenograft model. Also inhibits MDR-1 at high concentrations.
| Application: | MDM2 inhibitor |
| CAS | 1229705-06-9 |
| MW: | 616,5 D |
710.00€
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