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Item number: Cay22141-5

AM095 is an orally bioavailable antagonist of lysophosphatidic acid receptor 1 (LPA1) with IC50 values of 25 and 23 nM in CHO cells expressing human or mouse receptors, respectively. It is selective for LPA1 over LPA2, LPA3, LPA4, and LPA5 (IC50s = >10,000 nM for human LPA2-5). It inhibits chemotaxis of CHO cells...

Keywords:	4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-[1,1'-biphenyl]-4-acetic acid
Application:	LPA1 antagonist
CAS	1228690-36-5
MW:	456.5 D

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AM095 free acid

Item number: TGM-T10293-100mg

Description: AM095 (free acid) is a potent LPA1 receptor antagonist with IC50 values of 0.98 µM for recombinant human LPA1 and 0.73 µM for recombinant mouse LPA1. Target: LPL Receptor, LPA Receptor. Smiles: C[C@@H](OC(=O)Nc1c(C)noc1-c1ccc(cc1)-c1ccc(CC(O)=O)cc1)c1ccccc1. References: Castelino FV, et al....

CAS	1228690-36-5
MW:	456.49 D

From 30.00€ *

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