Description: Sabutoclax (BI-97C1)(BI-97C1) is a pan-Bcl-2 inhibitor, including Bcl-xL, Bcl-2, Mcl-1 and Bfl-1 with IC50 of 0.31 µM, 0.32 µM, 0.20 µM and 0.62 µM, respectively. Target: BCL. Smiles: CC(CNC(=O)c1c(O)c(O)cc2c(O)c(c(C)cc12)-c1c(C)cc2c(C(=O)NC[C@H](C)c3ccccc3)c(O)c(O)cc2c1O)c1ccccc1. References: Yunhui...

Sabutoclax is a pan-inhibitor of the Bcl-2 family proteins Bcl-xL, Bcl-2, Mcl-1, and Bfl-1 (IC50s = 0.31, 0.32, 0.2, and 0.62 µM, respectively). It inhibits the proliferation of BP3 B cell lymphoma cells, as well as PC3 prostate and H460 lung cancer cells (IC50s = 0.049, 0.13, and 0.56 µM, respectively). Sabutoclax...