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CC-115
CC-115

Item number: Cay19420-1

CC-115 is a dual inhibitor of mammalian target of rapamycin (mTOR) and DNA protein kinase (DNA-PK, IC50s = 0.021 and 0.013 µM, respectively). It is selective for mTOR and DNA-PK over PI3Kalpha, ATM, and ATR (IC50s = 0.85, >30, and >30 µM, respectively). CC-115 inhibits growth in a panel of 123 cancer cell lines,...
Keywords: 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-pyrazino[2,3-b]pyrazin-2(1H)-one
Application: DNA-PK / mTOR inhibitor
CAS 1228013-15-7
MW: 336.4 D
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