GNF351 is a potent AhR (aryl hydrocarbon receptor) antagonist. Aryl hydrocarbon receptor (AhR) is a ligand-dependent nuclear receptor that functions as a transcription factor. It can follow a canonical signaling pathway where binding of ligands to the cytosolic AhR induces the formation of a complex that...

Description: GNF351 is a full antagonist of the aryl hydrocarbon receptor (AHR)with the capacity to inhibit both DRE-dependent and -independent activity. GNF351 is minimal toxicity in mouse or human keratinocytes. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR (IC50: 62 nM). Target: Aryl...