MK-3102 is an inhibitor of dipeptidyl peptidase 4 (DPP-4, IC50 = 1.6 nM). It is selective for DPP-4 over several proteases, including DPP-7, DPP-8, DPP-9, and fibroblast activation protein (FAP, IC50s = >67 µM for all), as well as the ion channels delayed-rectifier potassium current (Ikr), L-type voltage-gated...

Description: Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency. Target: DPP-4, Proteasome. Smiles: CS(=O)(=O)n1cc2CN(Cc2n1)[C@H]1CO[C@@H]([C@@H](N)C1)c1cc(F)ccc1F. References: Biftu T, et al. J Med Chem. 2014 Apr 24,57(8):3205-12.