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Skepinone-L
Item number: Cay16974-1
Skepinone-L is an ATP-competitive inhibitor of p38 MAPK isoform p38alpha (IC50s = 5 nM) and p38beta (97% inhibition at 1 µM). It has little effect on a range of other kinases, including p38gamma and p38delta. Skepinone-L dose-dependently blocks the phosphorylation of heat shock protein 27 (HSP27), a p38 MAPK...
| Keywords: | 2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one |
| Application: | p38alpha inhibitor |
| CAS | 1221485-83-1 |
| MW: | 425.4 D |
From 73.00€
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Skepinone-L
Item number: TGM-T6130-100mg
Description: Skepinone-L (CBS3830) is a selective inhibitor of p38 mitogen-activated protein kinase. Target: Autophagy, p38 MAPK. Smiles: OC[C@@H](O)COc1ccc2CCc3cc(Nc4ccc(F)cc4F)ccc3C(=O)c2c1. References: Koeberle SC, et al. Nat Chem Biol. 2011, 8(2), 141-143.
| Keywords: | CBS3830 |
| Application: | p38alpha inhibitor |
| CAS | 1221485-83-1 |
| MW: | 425.42 D |
From 31.00€
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