Description: ML202 is a highly specific allosteric activator of human pyruvate kinase M2 (hPK-M2), enhancing the cooperativity of phosphoenolpyruvate (PEP) binding with negligible effect on adenosine diphosphate (ADP) binding. Target: Others. Smiles: CN1C2=C(C3=C1C(=O)N(CC4=CC(OC)=CC=C4)N=C3)SC(S(C)=O)=C2

ML-202 is an activator of pyruvate kinase M2 (PKM2). It induces PMK2 activation in a cell-free assay with a 50% activation concentration (AC50) value of 73 nM.Formal Name: 4,6-dihydro-6-[(3-methoxyphenyl)methyl]-4-methyl-2-(methylsulfinyl)-5H-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one. CAS Number: 1221186-52-2....