2 products were found matching "1218942-37-0"!

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Item number: Cay17764-1

NADPH oxidase 1 (NOX1) and NOX4 generate reactive oxygen species (ROS) that are critical in regulating a variety of cellular functions but also contribute to many diseases. GKT137831 is a dual inhibitor of both NOX1 and NOX4 with Ki values in the range of 100 to 150 nM in cell-free assays of ROS production. It shows...

Keywords:	2-(2-chlorophenyl)-4-[3-(dimethylamino)phenyl]-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione
Application:	NOX1 & NOX4 inhibitor
CAS	1218942-37-0
MW:	394.9 D

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Setanaxib

Item number: TGM-T6099-2mg

Description: Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor. Target: Ferroptosis, NADPH-oxidase, NADPH. Smiles: CN(C)c1cccc(c1)-c1n(C)c(=O)cc2[nH]n(-c3ccccc3Cl)c(=O)c12. References: Aoyama T, et al. Hepatology. 2012, 56(6), 2316-2327.

Keywords:	GKT137831
Application:	NOX1 & NOX4 inhibitor
CAS	1218942-37-0
MW:	394.85 D

From 33.00€ *

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