Galnon is a galanin (GAL) receptor agonist (KD = 2.9 µM in Bowes cells expressing GAL1 receptors). It inhibits forskolin-induced adenylate cyclase activity in rat hippocampal membranes (EC50 = 10 µM). Galnon (2 mg/kg) reduces the maximal seizure score and increases the latency to first seizure in a mouse model of...

Description: Galnon is a novel non-peptide galanin receptor agonist (GAL1 and GAL2 with Ki of 11.7 and 34.1 µM respectively). Target: Neuropeptide Y Receptor. Smiles: C(C(O)=O)(F)(F)F.C(OC(N[C@@H](CC1CCCCC1)C(N[C@H](C(NC=2C=C3C(=CC2)C(C)=CC(=O)O3)=O)CCCCN)=O)=O)C4C=5C(C=6C4=CC=CC6)=CC=CC5. References: Quynh N T T ,...