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Item number: Cay22925-1

YM-298198 is a non-competitive antagonist of the metabotropic glutamate receptor type I (mGluR1, Ki = 19 nM). It is selective for mGluR1 over mGluR2-7 (IC50s = 0.016 and >10 µM, respectively). YM-298198 binds to rat cerebellum membranes (Ki = 20 nM). In vivo, YM-298198 (10 and 30 mg/kg, p.o.) increases nociceptive...

Keywords:	6-amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]benzimidazole-2-carboxamide, monohydrochloride
Application:	mGluR1 antagonist
CAS	1216398-09-2
MW:	378.9 D

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