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Item number: Cay30062-5

WZ8040 is an inhibitor of mutant EGF receptors (EGFRs) with IC50 values ranging from 2 to 306 nM in Ba/F3 cells. It is selective for EGFR mutants, including the EGFRDel E746_A750 and EGFRL858R mutations conferring gefitinib sensitivity and the EGFRDel E746_A750/T790M mutation conferring gefitinib resistance (IC50s =...

Keywords:	N-[3-[[5-chloro-2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]thio]phenyl]-2-propenamide
Application:	Mutant EGFR inhibitor
CAS	1214265-57-2
MW:	481 D

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WZ8040

Item number: TGM-T6734-100mg

Description: WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I). Target: EGFR. Smiles: CN1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Sc3cccc(NC(=O)C=C)c3)n2)cc1. References: Zhou W, et al. Nature, 2009, 462(7276), 1070-1074.

Application:	Mutant EGFR inhibitor
CAS	1214265-57-2
MW:	481.01 D

From 39.00€ *

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