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Item number: Cay18722-1

Oclacitinib is an inhibitor of the JAK family kinases JAK1, JAK2, JAK3, and TYK2 (IC50s = 10, 18, 99, and 84 nM, respectively). It is selective for JAK kinases over a panel of 38 additional kinases at 1 µM. Oclacitinib inhibits LPS-induced increases in IL-12 and TNF-alpha levels in murine bone marrow-derived...

Keywords:	PF-03394197, trans-N-methyl-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-cyclohexanemethanesulfonamide
Application:	JAK inhibitor
CAS	1208319-26-9
MW:	337.4 D

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Oclacitinib

Item number: TGM-T2012-100mg

Description: Oclacitinib (PF-03394197)(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM, not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nM). Target: JAK. Smiles: CNS(=O)(=O)C[C@H]1CC[C@@H](CC1)N(C)c1ncnc2[nH]ccc12. References: Gonzales AJ, et al. J Vet Pharmacol Ther. 2014...

Keywords:	PF-03394197
CAS	1208319-26-9
MW:	337.44 D

From 38.00€ *

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