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GDC-0349
Item number: Cay24058-500
GDC-0349 is a potent inhibitor of the mammalian target of rapamycin (mTOR, Ki = 3.8 nM). It is selective for mTOR over a panel of 266 kinases at a concentration of 1 µM. GDC-0349 inhibits proliferation of PC3 prostate cancer cells in vitro (EC50 = 270 nM) and induces caspase-dependent apoptosis in head and neck...
| Keywords: | N-ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-methyl-4-morpholinyl]-7-(3-oxetanyl)pyrido[3,4-d]pyrimidin-2-yl]phenyl]-urea |
| Application: | mTOR inhibitor |
| CAS | 1207360-89-1 |
| MW: | 452.6 D |
From 44.00€
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GDC-0349
Item number: LKT-G1310.1
GDC-0349 is an ATP-competitive inhibitor of mTOR that exhibits anticancer chemotherpeutic activity. GDC-0349 displays pre-clinical efficacy in vitro and in vivo.
| Keywords: | GDC0349 |
| Application: | mTOR inhibitor |
| CAS | 1207360-89-1 |
| MW: | 452.55 D |
From 200.00€
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