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BI-847325
Item number: TGM-T6785-100mg
Description: BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. Target: Aurora Kinase, Apoptosis, MEK. Smiles: CCNC(=O)C#Cc1ccc2\C(=C(\Nc3ccc(CN(C)C)cc3)c3ccccc3)C(=O)Nc2c1. References: Phadke MS, et al. Mol Cancer Ther....
| Application: | MEK / Aurora kinase inhibitor |
| CAS | 1207293-36-4 |
| MW: | 464.56 D |
From 45.00€
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BI-847325
Item number: Cay18301-1
BI-847325 is a selective dual MEK/Aurora kinase inhibitor with IC50 values of 3, 25, 15, 25, and 4 nM for X. laevis Aurora B, human Aurora A and Aurora C, and human MEK1 and MEK2, respectively. It can inhibit the growth and survival of both treatment-naive and drug-resistant melanoma cell lines, decreasing the...
| Keywords: | 3-[3-[[[4-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indol-6-yl]-N-ethyl-2-propynamide |
| Application: | MEK / Aurora kinase inhibitor |
| CAS | 1207293-36-4 |
| MW: | 464.6 D |
From 100.00€
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