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Item number: Cay42991-1

Cyclotraxin B is a cyclic peptide and negative allosteric modulator of tropomysin-related kinase B (TrkB). It inhibits BDNF-induced TrkB activity in a kinase receptor activation ELISA (KIRA-ELISA) using tetracycline-responsive CHO-K1 cells expressing recombinant human TrkB (TetOn-rhTrkB cells, IC50 = 0. nM). It also...

Keywords:	cyclic (1->11)-disulfide...
Application:	Cyclic peptide, negative allosteric TrkB modulator
CAS	1203586-72-4
MW:	1200.37 D

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Cyclotraxin B

Item number: TGM-TP2068-1mg

Description: Antagonist of TrkB receptors, inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to exhibit putative anxiolytic properties in mice. References: Constandil et al...

CAS	1203586-72-4
MW:	1200.36 D

885.00€ *

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