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NMS-P715
Item number: TGM-T12237-100mg
Description: NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM). Target: MAPK, MELK, Kinesin, Casein Kinase. Smiles: CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC(F)(F)F)C(=O)NC3CCN(C)CC3)nc-21. References: Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy...
| Application: | Mps1 (TTK) inhibitor |
| CAS | 1202055-32-0 |
| MW: | 676.73 D |
From 72.00€
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NMS-P715
Item number: Cay31613-1
NMS-P715 is an inhibitor of the spindle assembly checkpoint kinase Mps1/TTK (IC50 = 0.182 µM). It is selective for Mps1/TTK over a panel of 59 additional kinases (IC50s = >5 µM for all). NMS-P715 (1 µM) accelerates mitosis, reducing the length of mitosis by approximately 3-fold, in U2OS cells. It induces aneuploidy...
| Keywords: | N-(2,6-diethylphenyl)-4,5-dihydro-1-methyl-8-[[4-[[(1-methyl-4-piperidinyl)amino]carbonyl]-2-(trifluoromethoxy)phenyl]amin... |
| Application: | Mps1 (TTK) inhibitor |
| CAS | 1202055-32-0 |
| MW: | 676.7 D |
From 74.00€
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