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Item number: Cay20076-5

Cerdulatinib is a dual inhibitor of spleen tyrosine kinase (Syk) and Janus kinases (JAK, IC50s = 32, 12, 6, 8, and 0.5 nM for Syk, JAK1, JAK2, JAK3, and TYK2, respectively) and also exhibits nanomolar inhibition of other kinases. Syk is involved in the B cell receptor (BCR) pathway, and cerdulatinib inhibits...

Keywords:	PRT062070, PRT2070, 4-(cyclopropylamino)-2-[[4-[4-(ethylsulfonyl)-1-piperazinyl]phenyl]amino]-5-pyrimidinecarboxamide
Application:	Syk / JAK1 / JAK2 / JAK3 / TYK2 inhibitor
CAS	1198300-79-6
MW:	445.5 D

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Cerdulatinib

Item number: TGM-T2487-5mg

Description: Cerdulatinib (PRT2070) is an novel oral dual Syk/JAK inhibitor. Target: Tyrosine Kinases, JAK, Syk. Smiles: CCS(=O)(=O)N1CCN(CC1)c1ccc(Nc2ncc(C(N)=O)c(NC3CC3)n2)cc1. References: Guo A, et al. Dual SYK/JAK inhibition overcomes ibrutinib resistance in chronic lymphocytic leukemia: Cerdulatinib, but not...

Keywords:	PRT2070, PRT062070
Application:	Syk / JAK1 / JAK2 / JAK3 / TYK2 inhibitor
CAS	1198300-79-6
MW:	445.54 D

From 38.00€ *

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