Description: EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC. It is selective for c-MYC over N-MYC and L-MYC, and inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis. Target: c-Myc. Smiles:...

A covalent inhibitor of c-Myc, inhibits c-Myc-induced increases in transcriptional activity in a reporter assay using HEK293T cells (EC50 = 12.5 µM), reduces the proliferation of 231MFP cells at 50 µM, decreases tumor volume in a 231MFP mouse xenograft model at 50 mg/kg per day. Formulation: A solid. InChI:...