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UNC0224
UNC0224

Item number: Cay13631-5

The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0224 is...
Keywords: 7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolin...
Application: G9a HMTase inhibitor
CAS 1197196-48-7
MW: 485.7 D
From 72.00€ *
Review
UNC0224
UNC0224

Item number: TGM-T17203-100mg

Description: UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM. Target: Histone Methyltransferase. Smiles: COc1cc2c(NC3CCN(C)CC3)nc(nc2cc1OCCCN(C)C)N1CCCN(C)CC1. References: Liu F, et al. Protein lysine...
Application: G9a HMTase inhibitor
CAS 1197196-48-7
MW: 485.67 D
From 45.00€ *
Review