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PF-3845
Item number: Cay13279-1
Fatty acid amide hydrolase (FAAH) degrades N-acyl ethanolamines (NAEs), including the endocannabinoid arachidonoyl ethanolamide (AEA). PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 µM). It covalently binds FAAH on Ser241 at the catalytic site, resulting in prolonged elevation of AEA...
| Keywords: | N-3-pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide |
| Application: | FAAH inhibitor |
| CAS | 1196109-52-0 |
| MW: | 456.5 D |
From 44.00€
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PF-3845
Item number: TGM-T6043-100mg
Description: PF-3845 is a potent, selective, and irreversible FAAH inhibitor with a Ki of 230 nM, exhibiting negligible activity against FAAH2. Target: FAAH, Autophagy. Smiles: FC(F)(F)c1ccc(Oc2cccc(CC3CCN(CC3)C(=O)Nc3cccnc3)c2)nc1. References: Booker L, et al, Br J Pharmacol, 2012, 165(8), 2485-2496.
| Application: | FAAH inhibitor |
| CAS | 1196109-52-0 |
| MW: | 456.46 D |
From 34.00€
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