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Item number: Cay29425-10

Fruquintinib is a VEGFR inhibitor (IC50s = 33, 35, and 0.5 nM for VEGFR1, -2, and -3, respectively). It also inhibits RET, FGFR1, and c-Kit (IC50s = 128, 181, and 458 nM, respectively) in a panel of 253 kinases. Fruquintinib inhibits VEGF-A-induced proliferation of human umbilical vein endothelial cells (HUVECs) and...

Keywords:	HMPL-013, 6-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-3-benzofurancarboxamide
Application:	VEGFR inhibitor
CAS	1194506-26-7
MW:	393.4 D

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Fruquintinib

Item number: TGM-T2656-100mg

Description: Fruquintinib (HMPL-013) is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities. Target: VEGFR. Smiles: CNC(=O)c1c(C)oc2cc(Oc3ncnc4cc(OC)c(OC)cc34)ccc12. References: Gu Y, et al. Y ChemOthers...

Keywords:	HMPL-013
CAS	1194506-26-7
MW:	393.39 D

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