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CZC-25146
Item number: Cay22931-1
CZC-25146 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 = 4.76 nM for the human recombinant kinase). It also inhibits LRRK2G2019S, a mutant linked to neurotoxicity and Parkinson's disease, with an IC50 value of 6.87 nM. CZC-25146 is selective for LRRK2 over a panel of kinases in HeLa cell...
| Keywords: | N-[2-[[5-fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-methanesulfonamide |
| Application: | LRRK2 inhibitor |
| CAS | 1191911-26-8 |
| MW: | 488.5 D |
From 49.00€
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CZC-25146
Item number: TGM-T3053-100mg
Description: CZC-25146 (CHEMBL2397014) is an effective, specific and metabolically stable LRRK2 inhibitor with IC50 of 4.76/6.87 nM for wild-type LRRK2(Leucine-rich repeat kinase-2) and G2019S LRRK2, respectively. Target: LRRK2. Smiles: COc1cc(ccc1Nc1ncc(F)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCOCC1
| Keywords: | CHEMBL2397014 |
| Application: | LRRK2 inhibitor |
| CAS | 1191911-26-8 |
| MW: | 488.54 D |
From 30.00€
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