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Raf inhibitor 1 dihydrochloride
Item number: TGM-T4167-100mg
Description: Raf inhibitor 1 dihydrochloride (B-Raf inhibitor 1 dihydrochloride) is a potent and selective B-Raf inhibitor. Target: Raf. Smiles: Cl.Cl.Cc1ccc2c(Nc3ccc(Cl)cc3)nccc2c1Nc1ncccc1-c1ncnc2[nH]cnc12. References: Wang X, et al. J Med Chem. 2012 Sep 13,55(17): 7332-41.
| Keywords: | B-Raf inhibitor 1 dihydrochloride |
| Application: | B-Raf inhibitor |
| CAS | 1191385-19-9 |
| MW: | 551.86 D |
From 42.00€
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B-RAF Inhibitor 1 (hydrochloride)
Item number: Cay26792-1
B-RAF inhibitor 1 is an inhibitor of Raf kinases (Kis = 0.3, 1, and 1 nM for C-RAF, B-RAF, and B-RAFV600E, respectively). It is selective for the B-RAFV600E kinase domain over Lck, Tie2, KDR, and p38alpha (IC50s = 83, 120, 1,000, and >1,600 nM, respectively). B-RAF inhibitor 1 inhibits phosphorylation of ERK in A375...
| Keywords: | N1-(4-chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine, dihydrochloride |
| Application: | BRAF inhibitor |
| CAS | 1191385-19-9 |
| MW: | 551.9 D |
From 52.00€
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