3 products were found matching "1187594-09-7"!
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Baricitinib
Item number: Cay16707-25
Baricitinib is an inhibitor of JAK1 and JAK2 (IC50s = 0.0059 and 0.0057 µM, respectively). It is selective for JAK1 and JAK2 over JAK3, TYK2, c-Met, and checkpoint kinase 2 (Chk2, IC50s = >0.4, 0.053, >10, and >1 µM, respectively). Baricitinib inhibits IL-6-induced phosphorylation of STAT3 in isolated human...
| Keywords: | INCB 028050, LY3009104, 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile |
| Application: | JAK1 / JAK2 inhibitor |
| CAS | 1187594-09-7 |
| MW: | 371.4 D |
From 52.00€
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Baricitinib
Item number: AG-CR1-3734-M010
White to off-white solid. Soluble in DMSO (30mg/ml) or DMF (40mg/ml). Chemical. CAS: 1187594-09-7. Formula: C16H17N7O2S. MW: 371.4. Baricitinib is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (IC50 = 5.9nM) and JAK2 (IC50 = 5.7nM) and inhibits Tyk2 (IC50 = 53nM). It...
| Keywords: | LY3009104, INCB28050, 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile |
| Application: | JAK1/JAK2 inhibitor |
| CAS | 1187594-09-7 |
| MW: | 371,4 D |
From 22.00€
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Baricitinib
Item number: TGM-T2485-100mg
Description: Baricitinib (INCB028050) is a JAK1 and JAK2 inhibitor (IC50=5.9/5.7 nM) with selective and oral activity. Baricitinib has potential anti-inflammatory, immunomodulatory and anti-tumor activity. Target: JAK, Tyrosine Kinases, Chk. Smiles: CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1[nH]cnc2nccc12. References:...
| Keywords: | INCB028050, LY3009104 |
| Application: | Targets Janus kinase 1 [EC:2.7.10.2] (JAK1) |
| CAS | 1187594-09-7 |
| MW: | 371.42 D |
From 43.00€
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