- Search results for 1187594-09-7
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3 products were found matching "1187594-09-7"!
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Item number: Cay16707-25
Baricitinib is an inhibitor of JAK1 and JAK2 (IC50s = 0.0059 and 0.0057 µM, respectively). It is selective for JAK1 and JAK2 over JAK3, TYK2, c-Met, and checkpoint kinase 2 (Chk2, IC50s = >0.4, 0.053, >10, and >1 µM, respectively). Baricitinib inhibits IL-6-induced phosphorylation of STAT3 in isolated human...
Keywords: | INCB 028050, LY3009104, 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile |
Application: | JAK1 / JAK2 inhibitor |
CAS | 1187594-09-7 |
MW: | 371.4 D |
From 50.00€
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-10 %
Item number: AG-CR1-3734-M010
White to off-white solid. Soluble in DMSO (30mg/ml) or DMF (40mg/ml). Chemical. CAS: 1187594-09-7. Formula: C16H17N7O2S. MW: 371.4. Baricitinib is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (IC50 = 5.9nM) and JAK2 (IC50 = 5.7nM) and inhibits Tyk2 (IC50 = 53nM). It...
Keywords: | LY3009104, INCB28050, 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile |
Application: | JAK1/JAK2 inhibitor |
CAS | 1187594-09-7 |
MW: | 371,4 D |
22.00€
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From 19.80€
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Item number: LC-B-1600_200mg
Soluble in DMSO. Baricitinib, also known as INCB028050, is a janus kinase (JAK) inhibitor. It potently and selectively inhibited JAK1 and JAK2 kinases with IC50 values of 5.9 nM and 5.7 nM, respectively. It inhibited intracellular signaling of multiple proinflammatory cytokines including IL-6 and IL-23, with IC50...
Keywords: | NCB028050, LY3009104 |
Application: | Antiinflammatory, Antirheumatic, Immunosuppressant, Janus kinase (JAK) inhibitor |
CAS | 1187594-09-7 |
MW: | 371.42 D |
From 82.00€
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