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Baricitinib
Baricitinib

Item number: Cay16707-25

Baricitinib is an inhibitor of JAK1 and JAK2 (IC50s = 0.0059 and 0.0057 µM, respectively). It is selective for JAK1 and JAK2 over JAK3, TYK2, c-Met, and checkpoint kinase 2 (Chk2, IC50s = >0.4, 0.053, >10, and >1 µM, respectively). Baricitinib inhibits IL-6-induced phosphorylation of STAT3 in isolated human...
Keywords: INCB 028050, LY3009104, 1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile
Application: JAK1 / JAK2 inhibitor
CAS 1187594-09-7
MW: 371.4 D
From 50.00€ *
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-10 %
Baricitinib
Baricitinib

Item number: AG-CR1-3734-M010

White to off-white solid. Soluble in DMSO (30mg/ml) or DMF (40mg/ml). Chemical. CAS: 1187594-09-7. Formula: C16H17N7O2S. MW: 371.4. Baricitinib is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (IC50 = 5.9nM) and JAK2 (IC50 = 5.7nM) and inhibits Tyk2 (IC50 = 53nM). It...
Keywords: LY3009104, INCB28050, 1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidineacetonitrile
Application: JAK1/JAK2 inhibitor
CAS 1187594-09-7
MW: 371,4 D
22.00€ * From 19.80€ *
Review
Baricitinib, Free Base
Baricitinib, Free Base

Item number: LC-B-1600_200mg

Soluble in DMSO. Baricitinib, also known as INCB028050, is a janus kinase (JAK) inhibitor. It potently and selectively inhibited JAK1 and JAK2 kinases with IC50 values of 5.9 nM and 5.7 nM, respectively. It inhibited intracellular signaling of multiple proinflammatory cytokines including IL-6 and IL-23, with IC50...
Keywords: NCB028050, LY3009104
Application: Antiinflammatory, Antirheumatic, Immunosuppressant, Janus kinase (JAK) inhibitor
CAS 1187594-09-7
MW: 371.42 D
From 82.00€ *
Review