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Trametinib (DMSO solvate)
Item number: Cay44750-10
Trametinib is an inhibitor of MEK1 and -2. It inhibits B-RAF- and C-RAF-induced phosphorylation of MEK1 (IC50s = 3. and 1. nM, respectively) and MEK2 (IC50s = 1. and 0. nM, respectively). Trametinib inhibits the growth of two human colorectal cancer cell lines expressing mutant B-RAF (IC50s = 0. and 0. nM) and seven...
| Keywords: | GSK1120212, JTP-74057,... |
| Application: | MEK1/MEK2 inhibitor |
| CAS | 1187431-43-1 |
| MW: | 693.53 D |
From 34.00€
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Trametinib (DMSO solvate)
Item number: TGM-T5857-100mg
Description: Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a highly potent and selective MEK inhibitor that specifically inhibits MEK1/2 (IC50: 2 nM). Target: Apoptosis, MEK. Smiles: CS(C)=O.CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O. References: Abe H , Kikuchi S , Hayakawa...
| Keywords: | Trametinib DMSO solvate, GSK-1120212 (DMSO solvate), JTP-74057 (DMSO solvate), Trametinib dimethyl sulfoxide |
| Application: | Targets mitogen-activated protein kinase kinase 1 [EC:2.7.12.2] (MAP2K1, MEK1) |
| CAS | 1187431-43-1 |
| MW: | 693.53 D |
From 39.00€
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