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Item number: TGM-T5444-10mg

Description: CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications. Target: Potassium Channel. Smiles: Fc1ccc(\C=C2/SC(=NC2=O)N2CCCCN2)c(OC(=O)N2CCCC2)c1. References: Ferrini F, et al. Enhancing KCC2...

Keywords:	CLP-290
Application:	KCC2 activator prodrug
CAS	1181083-81-7
MW:	404.46 D

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CLP 290

Item number: Cay31448-1

CLP 290 is a carbamate prodrug form of the K+/Cl- cotransporter 2 (KCC2) activator CLP 257 (Cay-30948). It increases the mechanical paw withdrawal threshold in a rat model of peripheral nerve injury and reverses morphine-induced hyperalgesia in rats when administered at a dose of 100 mg/kg. CLP 290 (35 mg/kg) also...

Keywords:	1-pyrrolidinecarboxylic acid, 5-fluoro-2-[(Z)-[4-oxo-2-(tetrahydro-1(2H)-pyridazinyl)-5(4H)-thiazolylidene]methyl]phenyl...
Application:	KCC2 activator prodrug
CAS	1181083-81-7
MW:	404.5 D

From 45.00€ *

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