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PKI-402
Item number: LKT-P4132.1
PKI402 is an inhibitor of PI3K that is somewhat selective for p110 , it also inhibits mTORC1/2. PKI402 exhibits anticancer chemotherapeutic activity, inhibiting cell proliferation in vitro and suppressing tumor growth induced by a variety of cancer cells in vitro, such as breast cancer, glioma, and pancreatic cancer.
| Application: | PI3K p110 / mTORC1/2 inhibitor |
| CAS | 1173204-81-3 |
| MW: | 570.65 D |
From 215.00€
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PKI-402
Item number: Cay27664-1
PKI-402 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR, IC50s = 1.4, 9.2, and 1.7 nM for PI3Kalpha, PI3Kgamma, and mTOR, respectively). It reduces proliferation of MDA-MB-361 and PC3 cancer cells (IC50s = 8 and 21 nM, respectively) and inhibits phosphorylation of Akt in MDA-MB-361 cells (IC50 =...
| Keywords: | N-[4-[3-ethyl-7-(4-morpholinyl)-3H-1,2,3-triazolo[4,5-d]pyrimidin-5-yl]phenyl]-N'-[4-[(4-methyl-1-piperazinyl)carbonyl]phe... |
| Application: | PI3K, mTOR dual inhibitor |
| CAS | 1173204-81-3 |
| MW: | 570.6 D |
From 85.00€
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