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Item number: Cay16295-1

Metabotropic glutamate receptors (mGluRs) modulate brain excitability through diverse mechanisms. VU0361737 is a selective positive allosteric modulator (PAM) of mGluR4, displaying EC50 values of 110 and 240 nM for rat and human receptors, respectively. It has weak or no activity at other mGluRs. VU0361737 passes...

Keywords:	N-(4-chloro-3-methoxyphenyl)-2-pyridinecarboxamide
Application:	mGluR4 positive allosteric modulator
CAS	1161205-04-4
MW:	262.7 D

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VU0361737

Item number: TGM-T6726-100mg

Description: VU0361737 (ML-128) is a specific positive allosteric modulator (PAM) of the mGlu4 receptor with an EC50 of 240 nM for human receptors and 110 nM for rat receptors. It exhibits weak activity at mGlu5 and mGlu8 receptors and is inactive at mGlu1, mGlu2, mGlu3, mGlu6, and mGlu7 receptors. The compound can...

Keywords:	ML-128, VU 0361737
Application:	mGluR4 positive allosteric modulator
CAS	1161205-04-4
MW:	262.69 D

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