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Item number: Cay34411-10

VU0238429 is a positive allosteric modulator of M5 muscarinic acetylcholine receptors (mAChRs, EC50 = 1.16 µM in a calcium mobilization assay). It is selective for M5 mAChRs over M1, M2, M3, and M4 mAChRs in CHO cells expressing the human receptors (EC50s = >30 µM for all in calcium mobilization assays). VU0238429...

Keywords:	HY-12157, ML129, 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
Application:	Muscarinic M5 receptor positive allosteric modulator
CAS	1160247-92-6
MW:	351.3 D

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VU 0238429

Item number: TGM-T8007-100mg

Description: VU 0238429 (SCR-1481B1) is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 µM). Target: AChR. Smiles: COc1ccc(CN2C(=O)C(=O)c3cc(OC(F)(F)F)ccc23)cc1. References: Bridges TM, et al. Discovery of the first highly M5-preferring muscarinic...

Keywords:	SCR-1481B1, VU0238429
Application:	Muscarinic M5 receptor positive allosteric modulator
CAS	1160247-92-6
MW:	351.28 D

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