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Item number: TGM-T12531-100mg

Description: PQCA is a muscarinic M1 receptor-positive allosteric regulator, which is highly selective and effective. PQCA exhibited EC50 values of 49 nM in rhesus monkey and 135 nM in human M1 receptors, but showed no activity against other muscarinic receptors. PQCA is a potential compound for reducing cognitive...

CAS	1144504-35-7
MW:	388.42 D

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MSD-M1PAM

Item number: Cay41358-1

A positive allosteric modulator of M1 mAChRs, enhances ACh-induced calcium production in a calcium mobilization assay from 0.1-10 µM, reverses scopolamine-induced deficits in freezing behavior in mice from 1-30 mg/kg, attenuates deficits in self-ordered spatial search in cynomolgus macaques and in the object...

Keywords:	PQCA, 1-[[4-cyano-4-(2-pyridinyl)-1-piperidinyl]methyl]-4-oxo-4H-quinolizine-3-carboxylic acid
Application:	Muscarinic acetylcholine receptor M1 positive allosteric modulator
CAS	1144504-35-7
MW:	388.4 D

From 80.00€ *

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