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Item number: Cay12018-25

Autotaxin converts lysophosphatidylcholine to lysophosphatidic acid (LPA), which can mediate changes in cell proliferation, angiogenesis, and cytokine secretion. PF-8380 is a potent inhibitor of autotaxin (IC50 = 2.8 nM in an enzyme assay), the enzyme that converts lysophosphatidylcholine to lysophosphatidic acid...

Keywords:	4-[3-(2,3-dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-(3,5-dichlorophenyl)methyl ester-1-piperazinecarboxylic acid
Application:	Autotaxin Inhibitor
CAS	1144035-53-9
MW:	478.3 D

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NEW

PF-8380

Item number: TGM-T3631-100mg

Description: PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay, 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhibiting autotaxin, reduces LPA levels both in plasma and at the site of inflammation....

Application:	Autotaxin Inhibitor
CAS	1144035-53-9
MW:	478.33 D

From 37.00€ *

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