Description: Edicotinib (JNJ-527) is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT and FLT3 (IC50: 20 nM and 190 nM). It has the potential for Alzheimer's disease and rheumatoid arthritis treatment. Target: FLT,...

Edicotinib is an inhibitor of colony stimulating factor 1 receptor (CSF1R, IC50 = 3.2 nM). It is selective for CSF1R over KIT and FMS-related tyrosine kinase 3 (FLT3, IC50s = 20 and 190 nM, respectively). Edicotinib (0.1-1,000 nM) reduces CSF1-induced phosphorylation of CSF1R and ERK1/2 in N13 microglia. It reduces...