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Item number: TGM-T11188L-100mg

Description: Emixustat hydrochloride (ACU-4429 hydrochloride) strongly inhibits 11-cis-retinol production with IC50 values of 232 ± 3 nM. 11-cis-retinol Emixustat hydrochloride is a novel visual cycle modulator. Target: Others. Smiles: Cl.NCC[C@@H](O)c1cccc(OCC2CCCCC2)c1. References: Kiser PD, et al. Catalytic...

Keywords:	ACU-4429 hydrochloride
CAS	1141934-97-5
MW:	299.84 D

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ACU 4429 (hydrochloride)

Item number: Cay33242-1

ACU 4429 is an inhibitor of retinal pigment epithelium 65 (RPE65, IC50 = 4.4 nM), an enzyme that catalyzes the isomerization of 11-trans retinol to 11-cis retinol (Cay-33207) in the visual cycle. It reduces rod photoreceptor recovery in dark-adapted mice after photobleaching (ED50 = 0.21mg/kg) and reversibly...

Keywords:	(alphaR)-alpha-(2-aminoethyl)-3-(cyclohexylmethoxy)-benzenemethanol, monohydrochloride
Application:	Retinoid isomerohydrolase (RPE65) inhibitor
CAS	1141934-97-5
MW:	299.8 D

From 111.00€ *

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