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Item number: Cay18392-1

CX-5461 is an inhibitor of ribosomal RNA (rRNA) synthesis. It selectively inhibits RNA polymerase I-driven transcription of rRNA in HCT116, A375, and MIA PaCa-2 tumor cells (IC50s = 142, 113, and 54 nM, respectively) without affecting RNA polymerase II (IC50 > 25µM), DNA replication, or protein translation. At 50...

Keywords:	2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-5H-benzothiazolo[3,2-a][1,8]naphthyridi...
Application:	rRNA synthesis inhibitor
CAS	1138549-36-6
MW:	513.6 D

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CX-5461

Item number: SYN-3031-M001

Slightly soluble (<1mg/ml) in DMSO or ethanol. CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC(50) of 142nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.

Keywords:	Chantix, Champix
Application:	RNA polymerase I inhibitor
CAS	1138549-36-6
MW:	513.6 D

From 119.00€ *

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