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Item number: TGM-T84488-10mg

Description: URB447, a peripherally restricted CB1 cannabinoid antagonist with IC50 values of 313 nM for rat CB1 receptor and 41 nM for human CB2 receptor, effectively reduces food intake and body weight gain in mice. It achieves these effects without penetrating the brain or antagonizing central CB1-dependent...

Application:	CB1 receptor antagonist, CB2 receptor agonist
CAS	1132922-57-6
MW:	400.9 D

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URB447

Item number: Cay13261-25

URB447 is a cannabinoid 1 (CB1) receptor antagonist and CB2 receptor agonist. It inhibits the binding of the CB receptor agonist [3H]-WIN 55,212-2 to CHO-K1 cells expressing the human CB2 receptor or rat cerebellar membranes (IC50s = 41 and 313 nM, respectively). URB447 (20 mg/kg) reduces food intake and weight gain...

Keywords:	[4-amino-1-[(4-chlorophenyl)methyl]-2-methyl-5-phenyl-1H-pyrrol-3-yl]phenyl-methanone
Application:	CB1 receptor antagonist, CB2 receptor agonist
CAS	1132922-57-6
MW:	400.9 D

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