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UCN-01
Item number: Cay18130-1
UCN-01 is a synthetic derivative of staurosporine (Cay-81590) with antiproliferative activity against several in vitro and in vivo cancer models. It inhibits a variety of kinases, including Akt, protein kinase C (IC50 = 30 nM), PDK1 (IC50 = 6 nM) and cyclin-dependent kinases (IC50s = 300-600 nM for Cdk1 and Cdk2)....
| Keywords: | 7-hydroxy Staurosporine, NSC 638850,... |
| Application: | Apoptosis inducer |
| CAS | 112953-11-4 |
| MW: | 482.5 D |
274.00€
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Antibiotic UCN-01 (7-Hydroxystaurosporine, UCN-01)
Item number: A2297-39.1
Isolated from Streptomyces sp., Antibiotic UCN-01 inhibits protein kinase C (PKC) and cyclin-dependent kinase 2 (CDK2) resulting in accumulation of cells in the G1 phase and induction of apoptosis. UCN-01 also enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite...
| Keywords: | Antibiotic |
| Application: | Apoptosis inducer |
| CAS | 112953-11-4 |
784.00€
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UCN-01
Item number: TGM-T23495-1mg
Description: inhibitor of Akt, protein kinase C, PDK1 and cyclin-dependent kinases. Target: Others. Smiles: [H][C@]12C[C@@H](NC)[C@@H](OC)[C@](C)(O1)n1c3ccccc3c3c4[C@@H](O)NC(=O)c4c4c5ccccc5n2c4c13
| CAS | 112953-11-4 |
| MW: | 482.53 D |
1,420.00€
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