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Item number: Cay27308-10

ASP9521 is an inhibitor of 17beta-hydroxysteroid dehydrogenase type 5/aldo-keto reductase 1C3 (17beta-HSD5/AKR1C3, IC50 = 120 nM). It is selective for 17beta-HSD5/AKR1C3 over AKR1C2 (IC50 = 20 µM). ASP9521 inhibits conversion of androstenedione into testosterone by 17beta-HSD5/AKR1C3 (IC50s = 11 and 49 nM for human...

Keywords:	[4-(2-hydroxy-2-methylpropyl)-1-piperidinyl](5-methoxy-1H-indol-2-yl)-methanone
Application:	17beta-HSD5/AKR1C3 inhibitor
CAS	1126084-37-4
MW:	330.4 D

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ASP-9521

Item number: TGM-T4529-100mg

Description: ASP-9521 is an effective, specific and orally available AKR1C3 inhibitor (IC50: 11 nM, for human). Target: NADPH. Smiles: COc1ccc2[nH]c(cc2c1)C(=O)N1CCC(CC(C)(C)O)CC1. References: Kikuchi A, et al. In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of...

Keywords:	ASP9521
Application:	17beta-HSD5/AKR1C3 inhibitor
CAS	1126084-37-4
MW:	330.42 D

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