2 products were found matching "1125632-93-0"!
No results were found for the filter!
Takeda-6d
Item number: SYN-1168-M001
Soluble in DMSO. Takeda-6d has potent inhibitory activity in both B-RAF with an IC(50) of 7.0nM and VEGFR2 with an IC(50) of 2.2nM. Target: B-RAF - VEGFR2 , Kinase Group: TKL , Substrate: Serine-Threonine
| Keywords: | Takeda 6d |
| Application: | B-RAF / VEGFR2 inhibitor |
| CAS | 1125632-93-0 |
| MW: | 548 D |
From 256.00€
*
Takeda-6d
Item number: Cay35754-1
Takeda-6d is a dual inhibitor of RAF kinases and VEGFR2. It inhibits wild-type B-RAF, mutant B-RAFV600E, and C-RAF (IC50s = 12, 7, and 1.5 nM, respectively), as well as VEGFR2 (IC50 = 2.8 nM). Takeda-6d is selective for these kinases over a panel of 19 additional kinases (IC50s = >1,000 nM) but does inhibit FGFR3,...
| Keywords: | 2-chloro-3-(1-cyanocyclopropyl)-N-[5-[[2-[(cyclopropylcarbonyl)amino][5,4-b]pyridin-5-yl]oxy]-2-fluorophenyl]-benzamide |
| Application: | RAF kinases and VEGFR2 dual inhibitor |
| CAS | 1125632-93-0 |
| MW: | 548 D |
From 192.00€
*
