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Item number: TGM-T7817-100mg

Description: Aprocitentan (ACT-132577) is ETA and ETB antagonist . Target: Endothelin Receptor. Smiles: NS(=O)(=O)Nc1ncnc(OCCOc2ncc(Br)cn2)c1-c1ccc(Br)cc1. References: Trensz F , Bortolamiol C , Kramberg M , et al. PHARMACOLO GICALCHARA CTERIZATION OF APROCITENTAN, A DUAL ENDOTHELIN RECEPTOR ANTAGONIST, ALONE AND IN...

Keywords:	ACT-132577
Application:	Antihypertensive, Endothelin receptor antagonist
CAS	1103522-45-7
MW:	546.19 D

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Aprocitentan

Item number: Cay34915-1

Aprocitentan is a dual endothelin type A (ETA) and ETB receptor antagonist and an active metabolite of macitentan (Cay-23304). It is formed from macitentan by the cytochrome P450 (CYP) isoform CYP3A4. Aprocitentan inhibits increases in intracellular calcium induced by endothelin-1 (ET-1) in primary human pulmonary...

Keywords:	ACT-132577, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-sulfamide
Application:	Macitentan dual ETA / ETB receptor antagonist, active macitentan metabolite
CAS	1103522-45-7
MW:	546.2 D

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