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CCT 137690
Item number: TGM-T2611-100mg
Description: CCT 137690 is a highly specific and oral-available aurora kinase inhibitor, for aurora A(IC50=15 nM ), B(IC50=25 nM) and C(IC50=19 nM). Target: Apoptosis, Aurora Kinase. Smiles: CN1CCN(CC1)c1ccc(cc1)-c1nc2c(N3CCN(Cc4cc(C)on4)CC3)c(Br)cnc2[nH]1. References: Bavetsias V, et al. J Med Chem, 2010, 53(14),...
| Keywords: | CCT137690 |
| Application: | Aurora kinase inhibitor |
| CAS | 1095382-05-0 |
| MW: | 551.48 D |
From 52.00€
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CCT137690
Item number: Cay15552-10
CCT137690 is a potent inhibitor of Aurora kinases (IC50s = 15, 25 and 19 nM for Aurora A, B, and C, respectively). It also inhibits the receptor tyrosine kinase FLT3 as well as the constitutively active form of FLT3 bearing internal-tandem duplications (FLT3-ITD, IC50s = 1.2 and 4.9 nM, respectively). CCT137690 is...
| Keywords: | 6-bromo-7-[4-[(5-methyl-3-isoxazolyl)methyl]-1-piperazinyl]-2-[4-(4-methyl-1-piperazinyl)phenyl]-3H-imidazo[4,5-b]pyridine |
| Application: | Aurora kinase inhibitor |
| CAS | 1095382-05-0 |
| MW: | 551.5 D |
From 150.00€
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