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Poziotinib
Item number: Cay22437-1
Poziotinib is a potent inhibitor of EGFR family kinases with IC50 values of 3.2, 5.3, 23.5, 4.2, and 2.2 nM for wild-type EGFR, HER2, HER4, EGFRT790M, and EGFRL858R/T790M, respectively. It has greater than 100- to 1,000-fold selectivity for EGFR kinases over 30 other tested kinases in vitro. Poziotinib inhibits...
| Keywords: | HM781-36B, 1-[4-[[4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-2-propen-1-one |
| Application: | EGFR family kinase inhibitor |
| CAS | 1092364-38-9 |
| MW: | 491.3 D |
From 40.00€
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Poziotinib
Item number: TGM-T2630-100mg
Description: Poziotinib (NOV120101)(NOV120101, HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM). Target: EGFR, HER, Apoptosis. Smiles: COc1cc2ncnc(Nc3ccc(Cl)c(Cl)c3F)c2cc1OC1CCN(CC1)C(=O)C=C. References: Nam HJ, et al. Cancer Lett. 2011, 302(2), 155-165.
| Keywords: | NOV120101, HM781-36B |
| CAS | 1092364-38-9 |
| MW: | 491.34 D |
From 30.00€
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