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Item number: Cay21006-10

Ubiquitin isopeptidase inhibitor I induces caspase activation and apoptosis (IC50 = ~1.7 µM) through a Bcl-2-dependent and apoptosome-independent mitochondrial pathway that selectively inhibits ubiquitin isopeptidase activity (IC50 = ~30 µM). It has also been shown to induce necrosis in apoptosis-resistant DKO...

Keywords:	NSC 144303, tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one, 1,1-dioxide
Application:	Ubiquitin isopeptidase inhibitor
CAS	108477-18-5
MW:	414.4 D

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