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SR-3677
Item number: TGM-TQ0187-10mg
Description: SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM). Target: ROCK, Autophagy. Smiles: CN(C)CCOc1cc(ccc1NC(=O)C1COc2ccccc2O1)-c1cn[nH]c1. References: Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase...
| Application: | ROCK inhibitor |
| CAS | 1072959-67-1 |
| MW: | 408.45 D |
From 31.00€
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SR 3677
Item number: Cay16708-5
SR 3677 is a potent, ATP-competitive inhibitor of Rho-associated kinases (ROCKs) that shows greater potency against ROCK2 than ROCK1 in enzyme and cell-based assays (IC50 values are 3 and 56 nM, respectively). At 3 µM, SR 3677 inhibits only 5 (Akt3, Clk1, Clk2, Clk4, Lats2) out of 353 kinases with greater than 50%...
| Keywords: | N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide |
| Application: | ROCK inhibitor |
| CAS | 1072959-67-1 |
| MW: | 408.5 D |
From 61.00€
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SR3677
Item number: SYN-1083-M001
Soluble in DMSO. SR-3677 had an IC(50) of approximately 3nM in enzyme and cell based assays and had an off-target hit rate of 1.4% against 353 kinases, and inhibited only 3 out of 70 non-kinase enzymes and receptors. Pharmacology studies showed that 5 was efficacious in both, increasing ex vivo aqueous humor outflow...
| Keywords: | SR-3677 |
| Application: | ROCK2 inhibitor |
| CAS | 1072959-67-1 |
| MW: | 408,5 D |
From 154.00€
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