2 products were found matching "1072959-67-1"!

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Item number: Cay16708-5

SR 3677 is a potent, ATP-competitive inhibitor of Rho-associated kinases (ROCKs) that shows greater potency against ROCK2 than ROCK1 in enzyme and cell-based assays (IC50 values are 3 and 56 nM, respectively). At 3 µM, SR 3677 inhibits only 5 (Akt3, Clk1, Clk2, Clk4, Lats2) out of 353 kinases with greater than 50%...

Keywords:	N-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxin-2-carboxamide
Application:	ROCK inhibitor
CAS	1072959-67-1
MW:	408.5 D

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SR3677

Item number: SYN-1083-M001

Soluble in DMSO. SR-3677 had an IC(50) of approximately 3nM in enzyme and cell based assays and had an off-target hit rate of 1.4% against 353 kinases, and inhibited only 3 out of 70 non-kinase enzymes and receptors. Pharmacology studies showed that 5 was efficacious in both, increasing ex vivo aqueous humor outflow...

Keywords:	SR-3677
Application:	ROCK2 inhibitor
CAS	1072959-67-1
MW:	408,5 D

From 132.00€ *

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