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Item number: Cay18870-10

Lennox-Gastaut syndrome (LGS) is a severe pediatric epilepsy syndrome characterized by multiple seizure types. Rufinamide is an anticonvulsant. It inhibits the activation of voltage-gated sodium channel 1.1 (Nav1.1) when used at a concentration of 100 µM. Rufinamide inhibits Nav1.1, but not Nav1.2, Nav1.3, and...

Keywords:	CGP 33101, RUF 331, 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
Application:	Antiepileptic
CAS	106308-44-5
MW:	238.2 D

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Rufinamide

Item number: TGM-T2523-100mg

Description: Rufinamide (E 2080), a triazole derivative, is used as voltage-gated sodium channel blocker for the treatment of seizure disorders. Target: Sodium Channel. Smiles: NC(=O)C1=CN(CC2=C(F)C=CC=C2F)N=N1. References: Cheng-Hakimian A, et al. Int J Clin Pract,2006, 60(11), 1497-1501.

Keywords:	E 2080, RUF 331, CGP 33101
Application:	Targets voltage-gated sodium channel type I alpha (SCN1A, NAV1.1)
CAS	106308-44-5
MW:	238.19 D

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