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Item number: Cay16240-5

Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell...

Keywords:	XL 139, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-benzamide
Application:	Smo inhibitor
CAS	1059734-66-5
MW:	473.6 D

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BMS-833923

Item number: TGM-T2299-100mg

Description: BMS-833923 (XL-139), an orally bioavailable Smoothened antagonist, inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner (IC50: 21 nM). Target: Apoptosis, Smo, Hedgehog/Smoothened. Smiles: CNCc1ccc(C)c(NC(=O)c2ccc(Nc3nc(-c4ccccc4)c4ccccc4n3)cc2)c1. References: Tang JY, et al. Semin...

Keywords:	XL-139
CAS	1059734-66-5
MW:	473.57 D

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