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AT-13148
Item number: Cay21597-1
AT-13148 is an orally bioavailable and ATP-competitive multi-AGC kinase inhibitor. It inhibits Akt1, 2, and 3 (IC50s = 38, 402, and 50 nM, respectively), in addition to other AGC kinase family members p70S6K, PKA, ROCK1, and ROCK2 (IC50s = 3-8 nM). AT-13148 inhibits growth of cancer cell lines with genetic mutations...
| Keywords: | (alphaS)-alpha-(aminomethyl)-alpha-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)-benzenemethanol |
| Application: | AGC kinase inhibitor |
| CAS | 1056901-62-2 |
| MW: | 313.8 D |
From 56.00€
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AT13148
Item number: TGM-T2482-10mg
Description: AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II. Target: PKA, S6 Kinase, ROCK, Akt, SGK. Smiles: NC[C@@](O)(c1ccc(Cl)cc1)c1ccc(cc1)-c1cn[nH]c1. References: Yap TA, et al. Clin Cancer Res. 2012, 18(14), 3912-3923.
| Application: | AGC kinase inhibitor |
| CAS | 1056901-62-2 |
| MW: | 313.78 D |
From 39.00€
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