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CYT387
Item number: Cay16246-1
CYT387 is an ATP-competitive inhibitor of the Janus kinases JAK1 and JAK2 (IC50s = 11 and 18 nM, respectively). It displays significantly less activity against other kinases, including JAK3 (IC50 = 0.16 µM). At 0.5 to 1.5 µM, CYT387 causes growth suppression and apoptosis in JAK2-dependent hematopoietic cell lines....
| Keywords: | Momelotinib, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]-benzamide |
| Application: | JAK1 / JAK2 inhibitor |
| CAS | 1056634-68-4 |
| MW: | 414.5 D |
From 109.00€
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Momelotinib
Item number: SYN-1035-M001
Soluble in DMSO. CYT387 is selective inhibitor of JAK1 and JAK2 kinases including the JAK2V617F mutant . Using ATP kinase assays IC(50) values for JAK1 (11nm), JAK2, (18nM), JAK2, JAK2V617F (23nM) JAK3 (155nM), and TYK2 (17nM). In testing kinase arrays, CYT387 also had activity (defined as an IC(50) < 100nM)...
| Keywords: | CYT387, Momelotinib |
| Application: | JAK1 / JAK2 inhibitor |
| CAS | 1056634-68-4 |
| MW: | 414,5 D |
From 106.00€
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CYT-387
Item number: LKT-C9876.1
JAK2 inhibitor.
| Keywords: | CYT387, CYT11387, Momelotinib |
| Application: | Janus kinase 1 (JAK1) inhibitor, janus kinase 2 (JAK2) inhibitor |
| CAS | 1056634-68-4 |
| MW: | 414.46 D |
From 135.00€
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