A potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which is often due to subarachnoid hemorrhage, as well as to improve the cognitive decline seen in stroke victims. It has been found to be effective for the treatment of pulmonary...

Description: Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 µM, 1.0 µM, 9.3 µM and 55 µM, respectively. Target: PKA, Calcium Channel, Autophagy, PKC, Serine/threonin kinase, ROCK, HIV Protease. Smiles: C1CNCCN(C1)S(=O)(=O)c1cccc2c1ccnc2.Cl. References:...

The monohydrochloride salt is the form used to prepare formulations of this drug for clinical use. Note that the solubility properties of the mono- and di-HCl salts are different. Kinase inhibitor, has antivasospastic properties. Solubility: Very soluble in water, up to about 175mg/ml , soluble in DMSO up to about...

A potent Rho-kinase inhibitor and vasodilator. Since it was discovered, it has been used for the treatment of cerebral vasospasm, which is often due to subarachnoid hemorrhage, as well as to improve the cognitive decline seen in stroke victims. It has been found to be effective for the treatment of pulmonary...