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Apoptozole
Item number: Cay17675-10
Apoptozole is an inhibitor of heat shock protein 70 (Hsp70, 65% inhibition at 200 µM) that acts by blocking its ATPase activity. It does not act on Hsp40, Hsp60, or Hsp90. Apoptozole dose-dependently induces apoptosis in cancer cells (IC50 = 5-7 µM). It prevents the association of Hsp70 with apoptotic...
| Keywords: | Apoptosis Activator VII, 4-[[2-[3,5-bis(trifluoromethyl)phenyl]-4,5-bis(4-methoxyphenyl)-1H-imidazol-1-yl]methyl]-benzamide |
| Application: | Hsp70 inhibitor |
| CAS | 1054543-47-3 |
| MW: | 625.6 D |
From 110.00€
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Apoptozole
Item number: TGM-T3293-100mg
Description: Apoptozole (Apoptosis Activator VII) inhibits the ATPase domain of Hsc70 and Hsp70, inducing apoptosis. Target: HSP, Apoptosis. Smiles: COc1ccc(cc1)-c1nc(-c2cc(cc(c2)C(F)(F)F)C(F)(F)F)n(Cc2ccc(cc2)C(N)=O)c1-c1ccc(OC)cc1. References: Williams DR, et al. Angew Chem Int Ed Engl. 2008, 47(39):7466-9.
| Keywords: | Apoptosis Activator VII |
| Application: | Hsp70 inhibitor |
| CAS | 1054543-47-3 |
| MW: | 625.56 D |
From 30.00€
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